As Shiryab kept the ingredients he used to make his tooth powder a secret, the ingredients he used to make the tooth powder remained unknown to the outside world until the end. Shiryap's toothpaste, which was delicious and fragrant, never fails to refresh and refresh the teeth like today's modern toothpaste. It is noteworthy that his tooth powder, accepted by everyone as the world's first tooth powder, was very popular among the Spanish people at that time.

However, it is no exaggeration to say that ash was the main tooth powder of people living in most countries of the world until the 18th century AD. As the tooth powder industry was also carried out as a cottage industry, there was no opportunity for cross border export and import of tooth powder, so till 1950 ash was the main tooth powder in most countries. Another surprising fact is that the practice of brushing teeth was not practiced among the people of England and America until the 18th century AD. It's hard to believe but it's true.

It was only in the beginning of the 18th century AD that the habit of brushing teeth started in England, followed by the habit of brushing teeth among the American population. Initially they used ash and eventually started brushing their teeth with ground powder of salt, alum and cinnamon. Subsequently, in 1824 AD, Dr. Peabody, a dentist from England, recommended using detergent soap along with other raw materials used to make tooth powder. It's not surprising that many of you reading now remember brushing your teeth with saltpeter in your childhood. Subsequently, in 1850, John Harris (Dr. John Harris, Dentist) from England and another dentist recommended to add chalk to the above raw materials.

Colgate was started by William Colgate (William Colgate, 1783 – 1857) in New York City in 1806 and sold various products.

Tooth powders made with lime began to cause some side effects in humans within a few days, so people's attention turned back to ash. At that time, an important turning point in history was an English dentist named Washington Wentworth Sheffield who developed a technology for making toothpaste with naturally occurring calcium fluoride. Discovered in 1892. In 1894, he discovered the technology of making collapsible tubes for continuous sale of toothpaste. Before Shepild got the patent for both, Colgate Company started to produce toothpaste based on the same technology and put it in tubes and sell it in the market under the name of Colgate Toothpaste.