Trisha began her movie career as a supporting actress with the movie Jodi in 1999. In this movie she is friend of lead actress whose name in this movie was Simran. The primary venture she acknowledged was the Priyadarshan-coordinated Lesa, with the limited time banners for the film, additionally making a proposal to star in the A R Rahman melodic hit, Enakku 20 Unakku 18 (2003). The film turned into a moderate accomplishment in the cinematic world and figured out how to acquire certifications for Trisha, with pundits asserting that she was "without a doubt a reviving new find, with shining eyes and engaging disposition", additionally going onto acclaim the naming artiste, Savitha Reddy, who has since routinely named for Trisha.Manasellam, her subsequent task, saw her play a disease patient; yet the film went undetected regardless of positive audits for the film and the entertainer.

Her subsequent movie was Samy with Vikram which is directed by Hari. This movie was based on the story of a Policeman life in this movie she played a college girl role and received appreciation from audience and reviewing authorities. 

She did her first telugu movie Varsham in 2004 which is a romantic action movie directed by MS Raju and Varsham turned her into an overnight sensation.

Her upcoming release was Aadavari Matalaku Ardhalu Verule with Famous Actor Venkatesh. She did a comedy movie Kireedam with Ajith Kumar which received lot of appreciations and love from audience after getting good response from audience media declared that the Kireedam is a successful movie.

Her 2009 movies Sarvam with Arya and Sankham inverse Gopichand didn't progress admirably and turned out to be simply normal grosser. Trisha had a significant job, featuring as a Syrian Christian Malayali young lady Jessie, in Gautham Menon's 2010 Tamil heartfelt show film Vinnaithaandi Varuvaayaa, which was a major business accomplishment in the cinematic world. The movie bases on the convoluted connection between a Syrian Christian Malayali young lady and a Tamil Hindu partner chief, who experiences passionate feelings for her, just to be met by her detachment and hesitance as they have a place with various religions and her exacting traditionalist family won't ever agree to their marriage. 

Her first solo movie was Namo Venkatesa which was released in 2010. This movie was based on the Lord Venkatesa. Her film dubut Bollywood was was Khatta Meetha with Akshay Kumar in 2010.

She Acted in Hey Jude Malayalam with in 2018 with Nivin Pauly. Presently she is working for three films namely Bhogi, Garjanai, and Patta with Famous Superstar Rajnikanth.

She won Best Actress at Filmfare Awards South, SIIMA Awards, Edison Awards, Norway Tamil Film Festival Awards and Ananda Vikatan Awards.