Love O2O is Chinese Romantic Drama. The story revolves around the virtual(game) and real world. Bei Wei Wei was a bright University student. In her free time, she plays The Chinese Ghost Story as Reed Wei Wei, and the in-game husband breaks up with her because she hesitating to share about her real life. Later, Reed Wei Wei and Yi Xiao He(top player) team up and get married. 

In Real world, Xiao (senior for Bei Wei Wei) a programmer begins a startup with his three bros. Yi Xiao He challenges Zhen hui(ex of Wei Wei in game) to a fight over his video with Enchantress(current wife in game) for mocking Wei Wei.

Cao(Foreign language student) pursues Wei Wei romantically but she has no interest in him. Wei Wei gets closer and closer to Xiao, this time sitting next to him in his father's lecture. Zhao Xi(Wei Wei's friend) begins gaming herself. Zhen Yi Technologies gives one of the bros a strange phone call to Ban Shan receives a huge offer from General Manager Li, but Xiao sees right through it. Wei Wei and Xiao beat the game and they end up in championship round; a dramatic turn for the worse puts them in a bad position for the championship, and leaves the Bros in a terrified state of disarray. 

Wei Wei is upset when Xiao doesn't turn up for the game because of an accident, it will upset her so much. Meanwhile Xi accepts an in-gaming confession. When Xiao wake up from concussion, he wants to meet Wei Wei in real life .Wei Wei is shocked to find out that Xiao is Yi Xiao He; he wants to date her, but she doesn't know if that's what she wants. The entire campus is gossiping about Xiao and Wei Wei being together.

 Xiao takes Wei Wei off-campus to his office and shows her his future plans for his game. Xiao heads to Shanghai for a reception. After a gossip appears on the school forum that Xiao only likes Wei Wei for her looks, her roommates plan to show up her rivals, but ends up a romantic evening for them. The school year is over and Wei Wei booked tickets foe her hometown. Both of them continue to talk even when they are separated. 

Work to complete the demo for `The New Chinese Ghost Story' speeds up. As per Wei Wei's request, Xiao hires her as an intern; her supervisor assigns her a complicated task on a tight deadline, but she is eager to tackle the challenge. Xi gets bitten by Coffee the cat and Cao  is worried she might get rabies. Xiao shows Wei Wei a demo of the game he's been working on. Sleeping Butterfly(player in game) is stunned by Reed Wei Wei's beauty in person then the other players in the game are also curious of Reed Wei Wei's identity and instigate the leader to host a meet up for the players.

Sleeping Butterfly  invites Wei Wei to a meet up of other players, where they try to cut her down to size;  Xi finally has everything she needs to make her beloved in game a special sword. Cao  mistook Xi as Wei Wei in game, mistaken identities in the game continue to wreak havoc in real life, leaving Wei Wei and Xi's friendship on the line. Wei Wei temporarily moves out of Xiao Ling's apartment and stay overnight at Xiao's. After discovering Reed Wei Wei's true identity, Zhen hui tries to pursue Wei Wei.

Wei Wei stays at Xiao's apartment, but he has to stay as well because of a flood. After both Xiao and Wei Wei take down Shao Xiang, he takes revenge by accepting a position at his father's company. Xiao learns that the game is now due earlier than expected and forces everyone to work around the clock. Xi gets approached with some bad news, she knows Wei Wei is innocent and she decides to tell sorry to Wei Wei about her mistake before. 

When Xiao struggles with the game's technical issues, it's up to Wei Wei to inspire him. Someone leaks information to a rival. On the presentation Xiao won the collaboration because of his smartness. The Company employees take a well-earned holiday for their celebration. Wei Wei receives a message from Shao Xiang that he is sorry for his wrongdoings and challenge to make a strong comeback. Two years later, Xiao calls Wei Wei his fiancée in an interview and make the world know about their relationship. Wei Wei and Xiao meet each other's parents and begin to plan their futures. Xiao and Wei Wei prepare wedding plans and their love continued…